This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search for products available from other suppliers or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.
Ayapana is used in the Amazon for headaches, colds and flu, mouth sores and ulcers, hypertension. and to relieve nausea and vomiting.* To learn more about this wonderful rainforest plant, go to the Tropical Plant Database file on Ayapana. To see pictures of ayapana, click here.
Traditional Uses:* as a stomachic for digestive problems (nausea, vomiting, stomachaches); for coughs, sore throat, colds, and bronchitis; for ulcers (mouth, skin, gastric); for cuts, scrapes, and wounds; for tumors
Suggested Use: 2 ml of a concentrated 1:4 extract 2-3 times daily or as needed.
Ayapana leaves contain naturally occurring coumarins. Coumarin has an anti-coagulant and blood thinning effect and is a precursor to coumadin drugs. Consult with your physician before taking this plant if you are taking coumadin drugs or if coumadin anticoagulant type drugs are contraindicated for your condition.
Drug Interactions: Ayapana may enhance or increase the effect of blood-thinning medications.
Third-Party Published Research*
All available third-party research on ayapana can be found at PubMed/Medline.
A partial listing of the published research on ayapana is shown below:
Bose, P. K., et al. “Haemostatic agents. Part II. Experiments with ayapanin and ayapin.” Nature 1937; 139: 515.
Bose. P.K., et al. “Haemostatic agents. Part I. Experiments with avapanin and ayapin.” Annals Biochem. Expt. Med. 1931; 1: 311-316.
da Souza, J. A., et al. “Blood coagulation activity of the Ayapin, (6,7-metilen-dioxy-coumarin) obtained from Alomia fastigiata Benth (Compositae).” Rev. Fac. Farm. Odontol. Araraquara. 1974 Jul-Dec; 8(2): 123-7.
Adaval, S. C., et al. “Effect of vitamin K 3 and ayapana on blood coagulation of normal buffalo calves.” Indian J. Physiol. Pharmacol. 1970 Jul; 14(3): 207.
Cytotoxic & Anticancerous Actions:
Riveiro, M., et al. "Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells." Bioorg. Med. Chem. 2009 Sep 15; 17(18): 6547-59.
Kawase, M., et al. “Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity.” In Vivo. 2005 Jul-Aug; 19(4): 705-11.
Watanabe, J., et al. “Coumarin and flavone derivatives from estragon and thyme as
inhibitors of chemical mediator release from RBL-2H3 Cells.” Biosci. Biotechnol. Biochem. 2005; 69(1): 1-6.
Riveiro, M., et al. "Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum." Cancer Lett. 2004 Jul 16; 210(2): 179-88.
Scio, E., et al. "Diterpenes from Alomia myriadenia (Asteraceae) with cytotoxic and trypanocidal activity." Phytochemistry. 2003 Nov;64(6): 1125-31.
Liver Protective Actions
Sancheti, S., et al. "Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats." Drug Chem Toxicol. 2013 Jan;36(1):42-7. doi: 10.3109/01480545.2011.648329. Epub 2012
Arung, R., et al. "Validation of Eupatorium triplinerve Vahl leaves, a skin care herb from East Kalimantan, using a melanin biosynthesis assay." J Acupunct Meridian Stud. 2012 Apr;5(2):87-92.
Narayanan, A., et al. "Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India. Benef Microbes. 2011 Sep;2(3):235-43.
Stein, A., et al. "Antifungal activity of some coumarins obtained from species of Pterocaulon (Asteraceae)." J. Ethnopharmacol. 2006 Aug 11; 107(1): 95-8.
Prsts, E., et al. "Antifungal activity of a new phenolic compound from capitulum of a head rot-resistant sunflower genotype." J. Chem. Ecol. 2007 Dec; 33(12): 2245-53.
Jelager, L., et al. “Antibacterial and antifungal activity of medicinal plants of Mauritius.” Pharmaceutical Biol. 1998; 36:153-161.
Gupta, M., et al. “Antimicrobial activity of Eupatorium ayapana.” Fitoterapia. 2002; 73 (2):168-170.
Verpoorter, R., et al. “Medicinal plants of Surinam. IV. Antimicrobial activity of some medicinal plants.” J. Ethnopharmacol. 1987; 21: 315-318.
Chaurasia, S. C., et al. “Activity of essential oils of three medicinal plants against various pathogenic and nonpathogenic fungi. Indian J. Hosp. Pharm. 1978; 15 pp. 139-141.
Sharma, S. K., et al. “The antifungal activity of some essential oils.” Indian Drugs Pharm Ind.. 1979; (14) 1: 3-6.
Garg, S. C., et al. “Studies on the essential oil from the flowers of Eupatorium triplinerve.” Indian Perfum 1993; 37 (4): 318-323.
Kokate, C. K., et al. “Pharmacological studies on the essential oil of Eupatorium triplinerve. I. Effects on the central nervous system and antimicrobial activity.” Flavour. 1971; 2 (3): 177-180.
Insecticidal and Antifeedant Actions:
Vera, N., et al. "Toxicity and synergism in the feeding deterrence of some coumarins on Spodoptera frugiperda Smith (Lepidoptera: Noctuidae)." Chem. Biodivers. 2006 Jan; 3(1) :21-6.
Facknath, S., et al. “Response of three important insect pests of horticultural crops in Mauritius to extracts of Ayapana triplinervis.” Journal of Applied Entomology 1999b.
Lalljee B., et al. “Biocidal potential of Eupatorium ayapana extracts”. Book of Abstracts. Symposium on Integrated Pest Management for Sustainable Crop Production, 2-4 Dec. 1997, IARI, New Delhi, India. page 64.
* The statements contained herein have not been evaluated
by the Food and Drug Administration.
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Last updated 12-17-2012