This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.
Amazon Sinus Support was a formula of rainforest botanicals which have been traditionally used in South America for allergies and sinusitis.* For more information on the individual ingredients in Amazon Sinus Support, follow the links provided below to the plant database files in the Tropical Plant Database.
Ingredients: An herbal blend of nettle leaf, carqueja, gerv‚o, pic„o preto, yerba mate, jatoba, pau d'arco, and guaco. To prepare this natural remedy yourself: use 3 parts nettle leaf (don't use nettle root... it isn't the same), 2 parts carqueja, and one part each of gerv‚o, pic„o preto, yerba mate, jatoba, pau d'arco, and guaco. To make a small amount... "1 part" could be one tablespoon (you'd have 11 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce, or one cup, or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.
Suggested Use: Take 1-2 grams by weight (or about 1/2 to 1 teaspoon by volume) every 4-6 hours as needed.
Contraindications: None reported.
Drug Interactions: None reported.
Other Practitioner Observations:
- Several plants in this formula have been documented to reduce blood pressure in animal studies. Individuals with low blood pressure should be monitored for this possible effect.
- Yerba mate contains naturally occurring caffeine. Those sensitive to or allergic to caffeine should avoid this formula.
- Gerv‚o contains a small quantity of salicylic acid. Those allergic to aspirin or salicylic acid should not take this formula.
Third-Party Published Research*
This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.
Nettle (Urtica dioica)
The following research studies confirm nettle root's traditional uses for allergies.*
Dar, S., et al. "Pharmacological and toxicological evaluation of Urtica dioica." Pharm Biol. 2012 Oct 5. [Epub ahead of print]
Roschek, B., et al. "Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis." Phytother Res. 2009 Jul;23(7):920-6.
Helms, S., et al. "Natural treatment of chronic rhinosinusitis." Altern. Med. Rev. 2006 Sept; 11(3): 196-207.
Thornhill, S. M., et al. “Natural treatment of perennial allergic rhinitis.” Altern. Med. Rev. 2000; 5(5): 448-54.
Galelli, A., et al. “Urtica dioica agglutinin. A superantigenic lectin from stinging nettle rhizome.” J. Immunol. 1993; 151(4): 1821-31.
Mittman, P. “Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis.” Planta Med. 1990; 56(1): 44-7.
Carqueja (Baccharis sp)
Carqueja has been traditional used for allergies and sinus infections in South American herbal medicine systems for many years.*
de Oliveira, C., et al. "Phenolic enriched extract of Baccharis trimera presents anti-inflammatory and antioxidant activities." Molecules. 2012 Jan 23;17(1):1113-23.
Nogueira, N., et al."In vitro and in vivo toxicological evaluation of extract and fractions from Baccharis trimera with anti-inflammatory activity." J Ethnopharmacol. 2011 Nov 18;138(2):513-22.
Paul, E., et al. "Anti-inflammatory and Immunomodulatory Effects of Baccharis trimera Aqueous Extract on Induced Pleurisy in Rats and Lymphoproliferation In Vitro." Inflammation. 2009 Sep 15.
Abad, M. J., et al. “Anti-inflammatory activity of four Bolivian Baccharis species (Compositae).” J. Ethnopharmacol. 2006 Feb; 103(3): 338-44.
Samy, R., et al. "Therapeutic Potential of Plants as Anti-microbials for Drug Discovery." Evid Based Complement Alternat Med. 2010 September; 7(3): 283Ė294
Morales, G., et al. "Antimicrobial activity of three Baccharis species used in the traditional medicine of Northern Chile." Molecules. 2008; 13(4): 790-4.
Betoni, J., et al. "Synergism between plant extract and antimicrobial drugs used on Staphylococcus aureus diseases." Mem. Inst. Oswaldo Cruz. 2006 Jun; 101(4): 387-90.
Hnatyszyn, O., et al. “Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus
cavernosum of guinea pig.” Phytomedicine. 2003 Nov; 10(8): 669-74.
Gervâo (Stachytarpheta cayennensis)
Gervâo has been traditional used in the Amazon for various upper respiratory conditions as well as allergies.* A chemical in Gervâo (which is also found in other medicinal plants), acetoside or verbascoside, has been documented with anti-allery actions.*
Lee, J., et al. "Anti-asthmatic effects of phenylpropanoid glycosides from Clerodendron trichotomum leaves and Rumex gmelini herbes in conscious guinea-pigs challenged with aerosolized ovalbumin." Phytomedicine. 2011 Jan 15;18(2-3):134-42.
Lee, J. H., et al. "The effect of acteoside on histamine release and arachidonic acid release in RBL-2H3 mast cells." Arch. Pharm. Res. 2006 Jun; 29(6): 508-13.
Hazekamp, A., et al. “Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum
petasites.” J. Ethnopharmacol. 2001; 78(1): 45–9.
Sulaiman, M., et al. "Antinociceptive and anti-inflammatory effects of Stachytarpheta jamaicensis (L.) Vahl (Verbenaceae) in experimental animal models." Med Princ Pract. 2009;18(4):272-9.
Penido, C., et al. “Anti-inflammatory and anti-ulcerogenic properties of Stachytarpheta cayennensis (L.C. Rich) Vahl.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 225-33.
Picão Preto (Bidens pilosa)
Picão Preto has recently been documented with antihistamine actions.*
Matsumoto, T., et al. "Effects of Bidens pilosa L. var. radiata SCHERFF treated with enzyme on histamine-induced contraction of guinea pig ileum and on histamine release from mast cells." J Smooth Muscle Res. 2009 Jun;45(2-3):75-86
Wang, N. L., et al. "Two neolignan glucosides and antihistamine release activities from Bidens parviflora WILLD." Chem. Pharm. Bull. 2006 Aug; 54(8): 1190-2.
Adedapo, A., et al. "Comparison of the nutritive value and biological activities of the acetone, methanol and water extracts of the leaves of Bidens pilosa and Chenopodium album." Acta Pol Pharm. 2011 Jan-Feb;68(1):83-92.
Tobinaga, S., et al. "Isolation and identification of a potent antimalarial and antibacterial polyacetylene from Bidens pilosa." Planta Med. 2009 May;75(6):624-8.
Rojas, J. J., et al. "Screening for antimicrobial activity of ten medicinal plants used in Colombian folkloric medicine: A possible alternative in the treatment of non-nosocomial infections." BMC Complement. Altern. Med. 2006 Feb; 6(1):2
Yoshida, N., et al. "Bidens pilosa suppresses interleukin-1beta-induced cyclooxygenase-2 expression through the inhibition of mitogen activated protein kinases phosphorylation in normal human dermal fibroblasts." J. Dermatol. 2006; 33(10): 676-83.
Wu, J., et al. "Investigation of the extracts from Bidens pilosa Linn. var. radiata Sch. Bip. for antioxidant activities and cytotoxicity against human tumor cells." J Nat Med. 2013 Jan;67(1):17-26.
Kviecinski, M., et al. "Brazilian Bidens pilosa Linnť yields fraction containing quercetin-derived flavonoid with free radical scavenger activity and hepatoprotective effects." Libyan J Med. 2011 Jan 18;6.
Yerba Mate (Ilex paraguariensis)
Yerba Mate was included in this formula for it's natural caffeine content. Natural health practitioners often use small amount of caffeine for the relief of sinus headaches.*
Peralta, I., et al. "Prevention of Hydrogen Peroxide-Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds." Phytother Res. 2012 Apr 18.
Fernandes, E., et al. "Yerba mate (Ilex paraguariensis) enhances the gene modulation and activity of paraoxonase-2: in vitro and in vivo studies." Nutrition. 2012 Nov-Dec;28(11-12):1157-64.
Pereira, D., et al. "Influence of the traditional Brazilian drink Ilex paraguariensis tea on glucose homeostasis."
Phytomedicine. 2012 Jul 15;19(10):868-77.
Vieira, M., et al. "Phenolic acids and methylxanthines composition and antioxidant properties of mate (Ilex paraguariensis) residue." J Food Sci. 2010 Apr;75(3):C280-5.
Wnuk, M., et al. "Evaluation of the cyto- and genotoxic activity of yerba mate (Ilex paraguariensis) in human lymphocytes in vitro. Mutat Res. 2009 Sep-Oct;679(1-2):18-23
Matsunaga, K., et al. “Inhibitory action of Paraguayan medicinal plants on 5-lipoxygenase.” Natural Med. 2000; 54(3): 151–54.
Jatoba (Hymenaea courbaril)
Jatoba was included in this formula for it's documented anti-fungal actions as many are allergic to molds.*
Cavin, A., "Bioactive diterpenes from the fruits of Detarium microcarpum." J. Nat. Prod. 2006; 69(5): 768-73.
Abdel-Kader, M., et al. “Isolation and absolute configuration of ent-Halimane diterpenoids from Hymenaea
courbaril from the Suriname rain forest.” J. Nat. Prod. 2002; 65(1): 11-5.
Yang, D., et al. “Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.” Mycopathologia. 1999; 148(2): 79–82.
Hostettmann, K., et al. “Phytochemistry of plants used in traditional medicine.” Proceedings of the
Phytochemical Society of Europe. Clarendon Press, Oxford. 1995.
Rahalison, L., et al. “Screening for antifungal activity of Panamanian plants.” Inst. J. Pharmacog. 1993; 31(1): 68–76.
Verpoorte, R., et al. “Medicinal plants of Surinam. IV. Antimicrobial activity of some medicinal plants.” J. Ethnopharmacol. 1987; 21(3): 315–18.
Arrhenius, S.P., et al. “Inhibitory effects of Hymenaea and Copaifera leaf resins on the leaf fungus, Pestalotia subcuticulari.” Biochem. Syst. Ecol. 1983; 11(4): 361–66.
Pau d'arco (Tabebuia impetiginosa)
Pau d'arco has been traditionally used in South America for allergies and upper respiratory infections.* Preliminary research indicates it possesses broad spectrum antimicrobial actions as well as anti-inflammatory actions.*
Lee, M., et al. "Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae." Mol Med Report. 2012 Oct;6(4):791-6
Suo, M., et al. "Anti-inflammatory constituents from Tabebuia avellanedae." Fitoterapia. 2012 Dec;83(8):1484-8.
Byeon, S., et al. "In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae." J Ethnopharmacol. 2008 Sep 2;119(1):145-52.
Awale, S., et al. ”Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.” Chem. Pharm. Bull. 2005; 53(6): 710-3.
Hofling, J., et al. "Antimicrobial potential of some plant extracts against Candida species." Braz J Biol. 2010 Nov;70(4):1065-8.
Melo e Silva, F., et al. "Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants."
Mycoses. 2009 Nov;52(6):511-7.
Pereira, E. M., et al. "Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis." Ann. Clin. Microbiol. Antimicrob. 2006 Mar; 5: 5.
Park, B. S., et al. "Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori." J. Ethnopharmacol. 2006 Apr; 105(1-2): 255-62.
Park, B. S., et al. “Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria.” J. Agric. Food Chem. 2005 Feb; 23;53(4): 1152-7.
Park, B. S., et al. “Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori.” J. Ethnopharmacol. 2005 Dec;
Machado, T. B., et al. “In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus.” Int. J. Antimicrob. Agents. 2003; 21(3): 279-84.
Portillo, A., et al. “Antifungal activity of Paraguayan plants used in traditional medicine.” J. Ethnopharmacol. 2001; 76(1): 93–8.
Nagata, K., et al. “Antimicrobial activity of novel furanonaphthoquinone analogs.” Antimicrobial Agents Chemother. 1998; 42(3): 700–2.
Binutu, O. A., et al. “Antimicrobial potentials of some plant species of the Bignoniaceae family.” Afr. J. Med. Sci. 1994; 23(3): 269–73.
Giuraud, P., et al. “Comparison of antibacterial and antifungal activities of lapachol and b-lapachone.” Planta Med. 1994; 60: 373–74.
Guaco (Mikania guaco)
Preliminary reseach has reported that guaco has anti-allergy, cough suppressant, bronchodilator, and expectorant actions.*
Soares, L., et al. "Preparation of dry extract of Mikania glomerata Sprengel (Guaco) and determination of its coumarin levels by spectrophotometry and HPLC-UV." Molecules. 2012 Aug 29;17(9):10344-54.
Gasparetto, J., et al. "Development and validation of two methods based on high-performance liquid chromatography-tandem mass spectrometry for determining 1,2-benzopyrone, dihydrocoumarin, o-coumaric acid, syringaldehyde and kaurenoic acid in guaco extracts and pharmaceutical preparations." J Sep Sci. 2011 Apr;34(7):740-8
Freitas, T., et al. "Effects of Mikania glomerata Spreng. and Mikania laevigata Schultz Bip. ex Baker (Asteraceae) extracts on pulmonary inflammation and oxidative stress caused by acute coal dust exposure." J Med Food. 2008 Dec;11(4):761-6
Graca, C., et al. "In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea." J Ethnopharmacol. 2007 Jul 25;112(3):430-9.
dos Santos, S. C., et al. "LC characterisation of guaco medicinal extracts, Mikania laevigata and M. glomerata, and their effects on allergic pneumonitis." Planta Med. 2006 Jun; 72(8): 679-84.
Soares de Moura, R., et al. “Bronchodilator activity of Mikania glomerata Sprengel on human bronchi and guinea-pig trachea.” J. Pharm. Pharmacol. 2002; 54(2): 249-56.
Fierro, I. M., et al. “Studies on the anti-allergic activity of Mikania glomerata.” J. Ethnopharmacol. 1999; 66(1): 19-24.
Leite, M. G. R., et al. “Actividade bronchodilatora de Mikania glomerata, Justicia pectoralis e Torresea cearensis."
Simposio de Plantas Medicinais do Brazil. December 1992. Curitiba. Resumos. p. 21.
Oliveira, F., et al. “Caraterizacao cromatograpfica do extracto fluido de Mikania glomerata Sprengel.” Simposio de Plantas Medicinais do Brazil. December 1992. Curitiba. Resumos. p. 96.
*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 1-10-2013