120 capsules (650 mg each)
This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.
A synergistic formula of 7 rainforest botanicals to boost immune function.* For more information on the individual ingredients in Amazon Immune Support, follow the links provided below to the plant database files in the Tropical Plant Database.
Ingredients: A proprietary blend of cat's claw, anamu, mullaca, fedegoso, sarsaparilla, samambaia, and macela. To prepare this natural remedy yourself: use 4 parts cat's claw, 2 parts anamu and one part each of the remaining plants in the list. To make a small amount... "1 part" could be one tablespoon (you'd have 11 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.
Suggested Use: Take 1-2 grams (by weight) twice daily or take 1 teaspoon (by volume) twice daily.
Drug Interactions: Will reduce the effect of immunosupressive drugs. May enhance the effect of ACE-inhibitor and antihypertensive drugs.
- Not to be used during pregnancy, while breast-feeding or while seeking to become pregnant.
- Do not use before or following any organ or bone marrow transplant or skin graft due to its immunostimulant properties.*
Other Practitioner Observations: Several plants in this formula have shown in animal studies to lower blood pressure. Those with hypotension should monitor their blood pressure more closely for this possible effect.
Third-Party Published Research*
This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.
Cat's Claw (Uncaria tomentosa)
Domingues, A., et al. "Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?" J Ethnopharmacol. 2011 Sep 1;137(1):635-42.
Domingues, A., et al. "Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile." Phytother Res. 2011 Aug;25(8):1229-35
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Reis, S., et al. "Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2." Int. Immunopharmacol. 2008; 8(3): 468-76.
Holderness, J., et al. "Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells." J. Immunol. 2007 Nov; 179(10): 6468-78.
Groom, S., et al. "The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation." J. Med. Food. 2007 Mar; 10(1): 73-9.
Spelman, K., et al. "Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators." Altern. Med. Rev. 2006 Jun; 11(2): 128-50.
Eberlin, S., et al. “Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes.” Int. Immunopharmacol. 2005; 5(7-8):1235-46.
Deharo, E., et al. ”In vitro immunomodulatory activity of plants used by the Tacana ethnic group in Bolivia.” Phytomedicine. 2004 Sep; 11(6): 516-22.
Lamm, S., et al, “Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100." Phytomedicine. 2001; 8(4): 267–74.
Sheng Y, et al., “Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.” Phytomedicine. 2000; 7(2): 137–43.
Lemaire, I., et al. “Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato).” J. Ethnopharmacol. 1999; 64(2): 109–15.
Marina, M. D. “Evaluacion de la actividal immunoestimulante de Uncaria tomentosa (Willd.) DC. Una de gato en ratones albinos." Biodiversidad Salud. 1998; 1(1): 16–19.
Keplinger, H., et al. “Oxindole alkaloids having properties stimulating the immunologic system and preparation containing same.” United States patent 5,302,611; April 12, 1994
Wagner, H., et al. “Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung." Planta Med. 1985; 51: 419–23.
Hemingway, S. R. and J. D. Phillipson. “Alkaloids from South American species of Uncaria (Rubiaceae)." J. Pharm. Pharmacol. 1974 suppl.; 26: 113p.
Anamu (Petiveria alliacea)
Santander, S., et al. "Immunomodulatory effects of aqueous and organic fractions from Petiveria alliacea on human dendritic cells." Am J Chin Med. 2012;40(4):833-44
Williams, L. "Life's immunity as a normal distribution function: philosophies for the use of dibenzyl trisulphide in immunity enhancement and life extension." West Indian Med J. 2010 Oct;59(5):455.
Okada, Y., et al. "Antioxidant activity of the new thiosulfinate derivative, S-benzyl phenylmethanethiosulfinate, from Petiveria alliacea L." Org. Biomol. Chem. 2008 Mar 21; 6(6): 1097-102.
Queiroz, M. L., et al. “Cytokine profile and natural killer cell activity in Listeria monocytogenes infected mice treated orally with Petiveria alliacea extract. Immunopharmacol. Immunotoxicol. 2000 Aug; 22(3): 501-18.
Quadros, M. R., et al. “Petiveria alliacea L. extract protects mice against Listeria monocytogenes infection—effects on bone marrow progenitor cells.” Immunopharmacol. Immunotoxicol. 1999 Feb; 21(1): 109-24.
Williams, L., et al. “Immunomodulatory activities of Petiveria alliaceae L.” Phytother. Res. 1997; 11(3): 251253.
Rossi, V., “Effects of Petiveria alliacea L. on cell immunity.” Pharmacol. Res. 1993; 27(1): 111-12.
Marini, S., “Effects of Petiveria alliacea L. on cytokine production and natural killer cell activity.” Pharmacol. Res. 1993; 27(1): 107-08.
Mullaca (Physalis angulata)
Castro, D., et al. "Physalin B inhibits Trypanosoma cruzi infection in the gut of Rhodnius prolixus by affecting the immune system and microbiota." J Insect Physiol. 2012 Dec;58(12):1620-5.
Sun, L., et al. "Amelioration of systemic lupus erythematosus by Withangulatin A in MRL/lpr mice." J Cell Biochem. 2011 Sep;112(9):2376-82.
Brustolim, D., et al. "Activity of physalin F in a collagen-induced arthritis model." J Nat Prod. 2010 Aug 27;73(8):1323-6.
Yu, Y., et al. "Investigation of the immunosuppressive activity of Physalin H on T lymphocytes." Int Immunopharmacol. 2010 Mar;10(3):290-7.
Castro, D., et al. "Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities." J Insect Physiol. 2009 Jun;55(6):532-7.
Castro, D., et al. "Immune depression in Rhodnius prolixus by seco-steroids, physalins." J Insect Physiol. 2008 Mar;54(3):555-62.
Soares, M. B., et al. “Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection.” Int. Immunopharmacol. 2006; 6(3): 408-14.
Garcia, E. S., et all. “Trypanosoma rangeli: effects of physalin B on the immune reactions of the infected larvae of Rhodnius prolixus.” Exp. Parasitol. 2006; 112(1): 37-43.
Soares, M. B., et al. “Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L.” Eur. J. Pharmacol. 2003; 459(1): 107-12.
Lin, Y. S., et al. “Immunomodulatory activity of various fractions derived from Physalis angulata L. extract.” Amer. J. Chinese Med. 1992; 20(3/4): 233–43.
Shingu, K., et al. “Three new withanolides, physagulins E, F and G from Physalis angulata L." Chem. Pharm. Bull. 1992; 40(9): 2448–51.
Sakhibov, A. D., et al. “Immunosuppressive properties of vitasteroids.” Dokl. Akad. Nauk. Uzb. SSR. 1990; 1:43–45.
Fedegoso (Cassia occidentalis)
Bin-Hafeez, B., et al. "Protective effect of Cassia occidentalis L. on cyclophosphamide-induced suppression of humoral immunity in mice." J. Ethnopharmacol. 2001; 75(1): 13-18.
Sharma, N., et al. “In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis.” Drug Chem. Toxicol. 2000; 23(3): 477–84.
Sharma, N., et al. “Protective effect of Cassia occidentalis extract on chemical-induced chromosomal aberrations in mice.” Drug Chem. Toxicol. 1999; 22(4): 643–53.
Sarsaparilla (Smilax officinalis)
Chu, K. T., et al. “Smilaxin, a novel protein with immunostimulatory, antiproliferative, and HIV-1-reverse transcriptase inhibitory activities from fresh Smilax glabra rhizomes.” Biochem. Biophys. Res. Commun. 2005 Dec; 340(1): 118.
Jiang, J., et al. "Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats." J. Ethnopharmacol. 2003; 85(1): 53-9.
Chen, T., et al. "A new flavanone isolated from Rhizoma smilacis glabrae and the structural requirements for its derivatives for preventing immunological hepatocyte damage." Planta Med. 1999; 65(1): 56-9.
Ma, D., et al. ”Effect of sarsasapogenin and its derivatives on the stimulus coupled responses of human neutrophils.” Clin. Chim. Acta. 2001 Dec; 314(1-2): 107-12.
Samambaia (Polypodium sp.)
Reyes, E., et al. “Systemic immunomodulatory effects of Polypodium leucotomos as an adjuvant to PUVA therapy in generalized vitiligo: A pilot study.” J. Dermatol. Sci. 2006; 41(3): 213-6.
Nogal-Ruiz, J. J., “Modulation by Polypodium leucotomos extract of cytokine patterns in experimental trichomoniasis model.” Parasite. 2003 Mar; 10(1): 73-8.
Sempere-Ortells, J. M., et al. “Anapsos (Polypodium leucotomos) modulates lymphoid cells and the expression of adhesion molecules.” Pharmacol. Res. 2002; 46(2): 185–90.
Gonzalez, S., et al. “An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: Pathogenic relationships and therapeutic implications.” Anticancer Res. 2000; 20(3a): 1567–75.
Sempere-Ortells , J. M., et al. “Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines.” Br. J. Clin. Pharmacol. 1997; 43(1): 85–9.
Bernd, A., et al. “In vitro studies on the immunomodulating effects of Polypodium leucotomos extract on human leukocyte fractions.” Arzneimittelforschung. 1995; 45(8): 901–4.
Rayward, J. et al. ”Polypodium leucotomos (PL), an herbal extract, inhibits the proliferative response of T. lymphocytes to polyclonal mitogens.” Second Intl. Cong. on Biol. Response Modifiers, San Diego, U.S.A. 1993.
Tuominen, M., et al., “Enhancing effect of extract Polypodium leucotomos on the prevention of rejection on skin transplants” Phytotherapy Research 1991; 5: 234–37.
Macela (Achyrocline satureoides)
Cosentino, M., et al. "Immunomodulatory properties of Achyrocline satureioides (Lam.) D.C. infusion: a study on human leukocytes." J Ethnopharmacol. 2008 Mar 28;116(3):501-7.
Santos, A. L., et al. “Immunomodulatory effect of Achyrocline satureioides (Lam.) D.C. aqueous extracts.” Phytother. Res. 1999; 13(1):65–66.
Puhlmann J, et al. “Immunologically active metallic ion-containing polysaccharides of Achyrocline
satureioides.” Phytochemistry. 1992; 31(8): 2617-21.
Wagner, H., et al. “Immunostimulating polysaccharides (heteroglycanes) of higher plants.” Arzneimforsch. 1985; 35(7): 1069–75.
Wagner, H., et al. “Immunostimulating polysaccharides (heteroglycanes) of higher plants/preliminary
communication.” Arzneimforsch. 1984; 34(6): 659–61.
*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 12-24-2012